New Approach for Characterization of Post Translational Modified Peptides - Using Ion Trap MS with Combined ETD/CID Fragmentation
| Type: | Application |
Journal Article |
Expression Proteomics |
| Number: | Technology |
LCGC-0905 |
Ion Trap |
| Year | Products |
2005 |
HCTultra PTM discovery system |
| Author | |
Ralf Hartmer and Markus Lubeck |
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| Reference | |
THE LCGC APPLICATIONS BOOK September 2005 |
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Abstract |
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A novel tandem mass spectrometry instrument (PTM Discovery System™) offers the application of two different MS fragmentation techniques (i.e. collisionally induced dissociation, CID, and electron transfer dissociation, ETD) showing highly complementary fragmentation results. The information obtained from both techniques is ideally suited for the characterization of post translational modifications (PTM), such as phopshorylation. ETD based fragmentation shows a similar short duty cycle as common CID allowing fast peptide identification and characterization in combination with online separation techniques. |
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