Study of Noncovalent Protein/Ligand Complexes using micrOTOF Mass Spectrometer
| Type: | Application |
Application Note |
Expression Proteomics |
| Number: | Technology |
ET-08 |
OTOF |
| Year | Products |
2005 |
micrOTOF |
| Author | |
Guillaume Chevreux, Emmanuelle Leize, Alain Van Dorsselaer, Noelle Potier |
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| Reference | |
Abstract |
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A recent application of mass spectrometry is the study of biochemical interactions using a gentle ionization method like electrospray. The abilities of the electrospray micrOTOF mass spectrometer to detect noncovalent interactions are presently investigated using a series of protein/ligand models. This mass spectrometer appears well fitted for such application showing sensitivity and robustness as well as enough resolution to allow the study of multiprotein/ligands complexes of several kDa. |
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