High Resolution Lipid Profiling and Identification by Hyphenated HPTLC-MALDI-TOF/TOF
| Type: | Application |
Application Note |
Food & Environmental, Gen. Pharma & Chemistry, Clinical Proteomics |
| Number: | Technology |
MT-101 |
MALDI-TOF |
| Year | Products |
2010 |
ultrafleXtreme, ImagePrep, Compass flexImaging, TLC-MALDI Data Viewer, HPTLC-MALDI Adapter Target |
| Author | |
Martin Schürenberg(1), Beate Fuchs(2), Annabell Bischoff(2), Rosemarie Süß(2), Ulrike Anders(1), Detlev Suckau(1), Gertrud Morlock(3) and Jürgen Schiller(2); (1) Bruker Daltonik GmbH, Germany, (2) University of Leipzig, Germany, (3) University of Hohenheim, Stuttgart, Germany |
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| Reference | |
Bruker Daltonics Application Note MT-101 |
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Abstract |
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Combining HPTLC with MALDI-TOF MS provides a new method for high-resolution molecular analysis direct from a HPTLC plate. The highly automated, software-supported technique is suitable for analysis of lipids in clinical, nutritional, pharmaceutical and cosmetic studies. Two dimensional analysis by HPTLC and MALDI-TOF MS greatly simplifies the structural elucidation of lipids in mixtures and a subsequent targeted MS/MS acquisition further increases specificity. |
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