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Mass Spectrometry Update - News from Bruker Daltonics
BDAL 06
November 05, 2009
Protein Quantitation
Performance Factors of a targeted Label-free Protein Quantitation Approach
The maxis, a ultra-high resolution Qq-TOF mass spectrometer demonstrates outstanding capabilities for label-free quantitations in high-throughput applications. Equipped with a new nano-ESI sprayer, the instrument delivers accurate quantitation over 2-3 orders of magnitude in a complex biological mixture. Low abundant biomarker identifications are within easy reach.
Read more: 
IMSC 2009, Poster PWA 178
Protein Characterization
Tryptic Digests, Spatially Resolved
While Top-Down Analysis easily allows analysis of endogenous proteins and peptides in MALDI imaging, bottom-up analysis delivers additional benefits: Analysis of peptides from proteins too large for typical MALDI experiments, simplified ID of tryptic peptides compared to endogenous peptides and access to analysis of formalin-fixed paraffin embedded tissue (FFPE). The ImagePrep, with its ability to deliver small droplets onto tissue sections in a controlled manner, is well suited for on-tissue digests as shown in the application note MT-98.
Read more: MT-98
Ultrafast MS–MS Screening Applications
Confident Identification of Compounds at UHPLC Speed
The amaZon was demonstrated as a fast and reliable screening instrument. Library-based identification of compounds was achieved by ultrafast MS and MS–MS under polarity switching within extremely short UPLC gradients. With unsurpassed speed and sensitivity, the amaZon is the instrument of choice for compound screening with spectral libraries.
Read the article: “Zero Delay” Polarity Switching for Ultrafast MS–MS Screening Applications
Software
ProteinScape: Generation, Validation, and Publication Results following Publication Guidelines
Report generation made easy: ProteinScape, a proteomics database platform, stores MS data and search results in a project-related way, and makes data easily accessible for reporting and exporting. Within ProteinScape, all data, ID and Quantitation results are stored in a project tree. ProteinScape provides various output formats such as Clipboard, XLS, DOC or PDF and reports the complete results as required by major Proteomics journals.
Read more: IMSC 2009, Poster PMM-227
CompoundCrawler: Adding Structure Information to Sum Formulae!
Compass DataAnalysis 4.0 now is shipped with the brand-new plug-in “CompoundCrawler”. This software queries the sum formulae generated with SmartFormula™ against several databases like Metlin or Chemspider automatically. Thus, validation of sum formulae with compound structures is just a mouse-click away!
Learn more: Compass software suite
Redefining the Utility and Capabilites of Mass Spectrometry
- September 2009 Web Seminars Now available as Video on Demand -
Learn more about the latest developments in Mass Spectrometry for a variety of application areas including: Small Molecule Analysis, Proteomics, Molecular and Tissue Imaging, Food & Environmental Analysis, Petroleomics and Forensics.
Broadening the Capabilites and Applications of Ion Trap MS
Watch amaZon / ETD / Screening Webcasts
High Performance LCMS for Accurate Small Molecule Identification
Watch maXis / SmartFormula Webcasts
Expanding and Enhancing the Utility of MALDI-TOF MS
Watch ultrafleXtreme / Edmass Sequencing / MALDI Imaging Webcasts
Definitive and Innovative Answers from Complex Samples and Demanding Applications
Watch solariX / MALDI Imaging Webcasts
Meet us!
Meet Bruker Daltonics at the following Conferences and Exhibitions:
November 09 - 11, AAPS - American Association of Pharmaceutical Scientists, Los Angles, CA, USA
November 16 - 19 EAS - Eastern Analytical Symposium, Somerset, NJ, USA
November 18 - 21, Medica Düsseldorf, Düsseldorf, Germany
November 25 - 26, Biomarker discovery meets Lucid Proteomics: SELDI User Meeting, Düsseldorf, Germany
November 26 - 28 2009 Annual Meeting of Materials Research Society Taiwan, Taiwan
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Latest software versions available
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Bruker Daltonics Sales & Marketing Team
