A Direct Glimpse of Cross-Hybridization: Background-Passified Microarrays That Allow Mass-Spectrometric Detection of Captured Oligonucleotides
| Type: | Application |
Journal Article |
Functional Genomics |
| Number: | Technology |
10.1002/ ange.200461212 |
MALDI-TOF |
| Year | Products |
2005 |
Reflex IV |
| Author | |
Ulrich Plutowski, Clemens Richert |
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| Reference | |
Angewandte Chemie Volume 117, Issue 4 , Pages 627 - 631 |
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Abstract |
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Detecting DNA mismatches by using selfassembled monolayers (SAMs) which include regions of DNA-capture probes: The hybridization of complementary target DNA versus mismatched DNA is distinguished by MALDI-TOF mass spectrometry. The extent to which mismatched DNA can hybridize to capture probes depends on the type and position of the mismatch. Spots of higher wettability show the locations of DNA
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