GC/APCI-TOF MS: a new valuable tool for analysis of biofluids in metabolomics studies
| Type: | Application |
Poster |
Metabolomics Studies |
| Number: | Technology |
WPD-118 |
OTOF |
| Year | Products |
2009 |
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| Author | |
A. Carrasco-Pancorbo1, T. Pacchiarotta1, A. Kettani2, E. Nevedomskaya1, T. Arthen-Engeland3, T. Zey3, G. Zurek3, C. Baessmann3, A. M. Deelder1, O. A. Mayboroda1 |
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| Reference | |
Abstract |
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• Derivatization reaction is a crucial step and it is necessary to optimize its conditions in depth. • In the positive mode, mostly [M+H]+ ions are observed. • 25 compounds in the standard mixture were sucessfully detected. •Mass accuracies were excellent for the standards with errors of 1ppm and mSigma values at 4.3 in average. • The LOD values for the new GC-APCI-TOF-MS method were in the nanomolar range. • The GC-APCI-TOF MS method developed is an alternative for the analysis of metabolites in biological fluids. |
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