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micrOTOF-Q II

Unique power³ for discovery

Precise mass
SmartFormula 3D™
MS/MS

Do you need maximum confidence in your analytical system? Bruker Daltonics’ new micrOTOF-Q II™ ESI-Qq-TOF mass spectrometer features the very latest technology developments to provide maximum certainty in your research in Small Molecule Identification, Metabolomics or Proteomics. Easy formula determination of small molecules, metabolic studies, analysis of complex mixtures, digests and in-depth evaluation of intact proteins are key applications.

Ultimate Sensitivity from Next-generation Ion Funnel ESI source

The new Apollo II™ Electrospray ion source with its advanced optics dramatically improves ion transmission.

High-performance Q-q-front end

The micrOTOF-Q II features a superb quadrupole mass filter and a quadrupole collision cell for accumulation of parent and fragment ions prior to mass analysis. The entire range of fragment ions is available at increased sensitivity for the time-of-flight mass analysis.

Unequaled Mass Accuracy over a wide dynamic range

The micrOTOF-Q II reaches a mass accuracy of 1 - 2 ppm by brilliant time-of-flight systems with innovative detection technologies. The instrument shares the famous stability of micrOTOF over a wide dynamic range without tedious recalibration routines. The mass position is kept stable for hours during temperature changes and over a wide dynamic range with significant variations in sample concentration.

Stability & Specificity

Ultra stable mass accuracy provides unique 2mDa hrEICs (high resolution Extracted Ion Chromatograms), for unlimited target screening in forensics, food and environmental applications. 2 mDa hrEICs provide stunning specificity and chemical background reduction for reliable detection of minimal target amounts in complex samples.

SmartFormula determination

Three dimensions of information simultaneously raise your analytical tasks to unrivaled heights of confidence:

Measure with unequalled accurate mass
Validate with True Isotopic Pattern (TIP) analysis
Also benefit from accurate mass and TIP in analysis of fragments in MS/MS mode

Mass accuracy, chemical knowledge and SmartFormula 3D™ clearly limit the number of possible formulae in molecular formula generation: for confident determination of the elemental composition of a given peak.

This valuable sub-ppm confidence is available for formula determination in pharmaceutical impurity analysis, etabolite identification, pesticide screening and toxicology & doping analysis.

MS/MS performance

Bringing together the unprecedented features of Bruker Daltonics micrOTOF - the excellent mass accuracy on fragments and superb focus resolving power exceeding 17,500 FWHM - with flexible data dependant MS/MS strategies, the micrOTOF-Q II allows de novo sequencing of peptides even for post-translational modifications. Confident results in proteomics research meets accurate mass and structural analysis of small molecules.

A software environment for maximum productivity

Compass™, Bruker Daltonics unified software environment for all life science instruments, handles all system controls, allows full data management and provides full automation of the LC/MS workflow.

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Technical Data

Cutting-edge performance

World-leading combination of mass accuracy, resolution and sensitivity without compromise
Wide dynamic range for ultra-stable accurate mass
High-performance Q-q-front end
Footprint 640x949x1320 mm, weight 160 kg

Source options

Apollo II ion funnel ESI Electrospray source (1 µl – 1 ml/min)
APCI atmospheric pressure chemical ionization source (100 µl – 1,5 ml/min)
ESI/APCI multimode source
APPI atmospheric pressure photo ionization source
online / offline NanoElectrospray source
CE/MS coupling with grounded ESI needle

Analytical performance

Mass range 50 – 20,000 m/z
Mass accuracy in MS and MS/MS 1 - 2 ppm RMS Error (internal), 5 ppm RMS Error (external)
Mass resolution 17,500 (FWHM), typically 20,000 FWHM at LC-speed
Mass Stability Dynamic Range with better than 2mDa hrEICs (high resolution Extracted Ion Chromatograms)
Temperature compensated
Acquisition rate (2GHz sampling rate) 20 Hz (profile and peak detected spectra to disk)